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Analysis of Ultrafast Laser Propagation in Biological Tissues With Embedded Tumors and Large Blood Vessels

[+] Author Affiliations
Jianhua Zhou, Yuwen Zhang, J. K. Chen

University of Missouri at Columbia

Paper No. IMECE2006-13791, pp. 433-440; 8 pages
  • ASME 2006 International Mechanical Engineering Congress and Exposition
  • Heat Transfer, Volume 3
  • Chicago, Illinois, USA, November 5 – 10, 2006
  • Conference Sponsors: Heat Transfer Division
  • ISBN: 0-7918-4786-1 | eISBN: 0-7918-3790-4
  • Copyright © 2006 by ASME


Time-resolved optical imaging technique offers the promise for development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. However, the presence of mismatched refractive-index boundaries in a soft tissue will tremendously change light propagation path, which in turn, makes the optical image obscure if not indiscernible. In this article, a time-resolved Monte Carlo model, which takes into account the photon reflection/transmission behavior at the mismatched refractive-index boundaries, is developed to investigate transient light propagation in biological tissues with embedded tumors and blood vessels. The results show that the temporal reflection signal displays two peak values when refractive-index mismatched foreign objects, such as tumors or blood vessels, are embedded in the tissue. One peak is a direct result arising from the pulse nature of the incident laser light, and the other is due to the backscattering from the refractive-index mismatched boundaries. This suggests that the occurrence of the "second peak" be an indication for the location and size of tumors inside the tissue.

Copyright © 2006 by ASME



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