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A Microfluidic Based High Throughput Resistive Pulse Sensor

[+] Author Affiliations
Jiang Zhe, Ashish Jagtiani, Jun Hu, Joan Carletta

University of Akron

Nazmul Mamun, Prashanta Dutta

Washington State University

Paper No. IMECE2006-15540, pp. 195-200; 6 pages
doi:10.1115/IMECE2006-15540
From:
  • ASME 2006 International Mechanical Engineering Congress and Exposition
  • Fluids Engineering
  • Chicago, Illinois, USA, November 5 – 10, 2006
  • Conference Sponsors: Fluids Engineering Division
  • ISBN: 0-7918-4770-5 | eISBN: 0-7918-3790-4
  • Copyright © 2006 by ASME

abstract

We describe a micromachined. resistive pulse sensor with multiple sensing microchannels. A unique design placing measurement microelectrodes in the center of the microchannels is demonstrated. This design creates isolation resistances among channels and thus circumvents the crosstalk caused by automatic electrical connection among microchannels. When implemented using microscale channels, the design is appropriate for the sensing of microscale particles in deionized water or in very dilute electrolyte solution; using nanoscale channels, the design is appropriate for the sensing of nanoscale particles in electrolyte solutions of any concentration. The design has multiple channels operating in parallel, but integrated with just one sample reservoir and one power source. The results with a four-channel device show that this device is capable of differentiating and counting micro polymethacrylate particles and Juniper pollens rapidly. The throughput is improved significantly in comparison to a single channel device. The concept can be extended to a large number of sensing channels in a single chip for significant improvement in throughput.

Copyright © 2006 by ASME

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