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Real-Time Glucose Sensing Using a MEMS-Based Bi-Material Deflecting Membrane

[+] Author Affiliations
Sandeep Mariserla, Zayd Leseman

University of Illinois at Urbana-Champaign, Urbana, IL

Thomas J. Mackin

California Polytechnic State University, San Luis Obispo, CA

Paper No. NANOBIO2006-18013, pp. 21-22; 2 pages
  • ASME 2006 Frontiers in Biomedical Devices Conference
  • ASME 2006 Frontiers in Biomedical Devices Conference
  • Irvine, California, USA, June 8 – 9, 2006
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4763-2 | eISBN: 0-7918-3781-5
  • Copyright © 2006 by ASME


Self-monitoring of blood glucose has become an important and critical tool for effective management of diabetes. A closed-loop, real-time sensing and dispensing system, however, has been elusive. We describe here, a novel MEMS-based sensor intended to measure, in realtime, the concentration of glucose in a solution. The device utilizes a bi-material membrane with a functional hydrogel layer that swells reversibly, and in proportion to, the presence of glucose. The hydrogel is composed of 2-hydroxyethyl methacrylate (HEMA) functionalized with 3-acrylamidophenylboronic acid (AAPBA) groups as the glucose-sensitive moiety. Phenylboronic acid (PBA) derivatives interact with glucose by forming a charged complex, causing the hydrogel to swell by solvent intake [1].

Copyright © 2006 by ASME



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