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A New Direct Electron Imaging System for Biomedical Applications

[+] Author Affiliations
Shengdong Li, Stuart Kleinfelder

University of California at Irvine, Irvine, CA

Paper No. NANOBIO2006-18046, pp. 7-8; 2 pages
  • ASME 2006 Frontiers in Biomedical Devices Conference
  • ASME 2006 Frontiers in Biomedical Devices Conference
  • Irvine, California, USA, June 8 – 9, 2006
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4763-2 | eISBN: 0-7918-3781-5
  • Copyright © 2006 by ASME


High resolution electron imaging of biological assemblies such as proteins, viruses, and cells are important for biomedical diagnosis and drug discovery. We report on the design of a new CMOS direct-detection camera system for electron imaging. The active pixel sensor array includes 512 by 550 pixels, each 5 by 5 μm in size, with a ~8 μm epitaxial layer to achieve an effective fill factor of 100%. Spatial resolution of 2.3 μm for a single incident e- has been measured. A sample image of a mouse’s muscle cell is presented.

Copyright © 2006 by ASME



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