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A New Direct Electron Imaging System for Biomedical Applications

[+] Author Affiliations
Shengdong Li, Stuart Kleinfelder

University of California at Irvine, Irvine, CA

Paper No. NANOBIO2006-18046, pp. 7-8; 2 pages
doi:10.1115/NANOBIO2006-18046
From:
  • ASME 2006 Frontiers in Biomedical Devices Conference
  • ASME 2006 Frontiers in Biomedical Devices Conference
  • Irvine, California, USA, June 8 – 9, 2006
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4763-2 | eISBN: 0-7918-3781-5
  • Copyright © 2006 by ASME

abstract

High resolution electron imaging of biological assemblies such as proteins, viruses, and cells are important for biomedical diagnosis and drug discovery. We report on the design of a new CMOS direct-detection camera system for electron imaging. The active pixel sensor array includes 512 by 550 pixels, each 5 by 5 μm in size, with a ~8 μm epitaxial layer to achieve an effective fill factor of 100%. Spatial resolution of 2.3 μm for a single incident e- has been measured. A sample image of a mouse’s muscle cell is presented.

Copyright © 2006 by ASME

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