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Mechanical Response of Single Biological Cells to Externally Applied Forces

[+] Author Affiliations
B. A. Samuel, M. A. Haque

Pennsylvania State University, University Park, PA

Paper No. IMECE2007-43373, pp. 1089-1092; 4 pages
  • ASME 2007 International Mechanical Engineering Congress and Exposition
  • Volume 10: Mechanics of Solids and Structures, Parts A and B
  • Seattle, Washington, USA, November 11–15, 2007
  • Conference Sponsors: ASME
  • ISBN: 0-7918-4304-1 | eISBN: 0-7918-3812-9
  • Copyright © 2007 by ASME


We present an experimental technique capable of applying and measuring very small forces (nanoNewtons) on live biological cells. The technique is based on combing microfabricated molded elastomeric microneedles, and substrate deformation to actively apply loads on single cells. By using fluorescence and differential interference contrast imaging we can quantitatively study the response of biological cells to force exerted on it via the extra cellular matrix. Bovine Aortic Endothelial Cells were cultured on the micropillars and strained in-vitro to demonstrate the experimental technique.

Copyright © 2007 by ASME



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