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Nanomechanical Microcantilevers for In-Vitro Biomolecular Detection

[+] Author Affiliations
Kilho Eom, Tae Yun Kwon, Jinsung Park, Dae Sung Yoon, Tae Song Kim

Korea Institute of Science and Technology, Seoul, South Korea

Sungsoo Na

Korea University, Seoul, South Korea

Paper No. IMECE2007-41290, pp. 821-842; 22 pages
doi:10.1115/IMECE2007-41290
From:
  • ASME 2007 International Mechanical Engineering Congress and Exposition
  • Volume 10: Mechanics of Solids and Structures, Parts A and B
  • Seattle, Washington, USA, November 11–15, 2007
  • Conference Sponsors: ASME
  • ISBN: 0-7918-4304-1 | eISBN: 0-7918-3812-9
  • Copyright © 2007 by ASME

abstract

Nanomechanical microcantilevers have enabled the sensitive label-free detection of chemical and/or biological molecules. In recent years, resonating microcantilevers have achieved the unprecedented sensitivity in detecting molecules. In this article, we review our current works on the label-free detection of biomolecules based on resonating microcantilevers. Our piezoelectric thick film microcantilevers exhibit the relatively high quality factor in a viscous liquid, indicating the potential of our cantilever to in situ biosensor applications for real-time detection of biomolecular interactions. It is shown that our microcantilevers allow the noise-free real-time monitoring of biomolecular recognitions, providing the insight into kinetics of biomolecular recognitions.

Copyright © 2007 by ASME

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