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Modified Fading Memory Model to Describe ASM Dynamics

[+] Author Affiliations
Y. Du, A. M. Al-Jumaily

Auckland University of Technology, Auckland, New Zealand

Paper No. IMECE2007-41179, pp. 327-329; 3 pages
  • ASME 2007 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Seattle, Washington, USA, November 11–15, 2007
  • Conference Sponsors: ASME
  • ISBN: 0-7918-4296-7 | eISBN: 0-7918-3812-9
  • Copyright © 2007 by ASME


A modified fading memory model is introduced in this work to describe the behavior of airway smooth muscle dynamics. The model is used to simulate two biophysical cases: a finite duration for the step change in length and a case for external longitudinal oscillations. For both cases, the model describes the cross-bridge behaviour well and indicates that the muscle length change is the most important factor to determine the degree of cross-bridge detachment. However, the frequency of oscillation represents the velocity of the length change, which affects the cross-bridge cycling rate as reflected in the lower frequency range. The model is intended to interpret certain biophysical processes and not to accurately model the biophysical events underlying muscle contraction.

Copyright © 2007 by ASME



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