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HIFU-Induced Gene Activation in a Cell-Embedded Tissue Mimicking Phantom

[+] Author Affiliations
Fang Yuan, Chris Pua, Pei Zhong

Duke University, Durham, NC

Yunbo Liu

U.S. Food and Drug Administration, Rockville, MD

Paper No. IMECE2007-43996, pp. 323-324; 2 pages
doi:10.1115/IMECE2007-43996
From:
  • ASME 2007 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Seattle, Washington, USA, November 11–15, 2007
  • Conference Sponsors: ASME
  • ISBN: 0-7918-4296-7 | eISBN: 0-7918-3812-9
  • Copyright © 2007 by ASME

abstract

The synergistic integration of high intensity focused ultrasound (HIFU) thermal ablation and HIFU-induced gene therapy represents a promising approach in improving the overall efficacy and quality of cancer therapy. Previous studies have demonstrated that HIFU can induce GFP gene activation under the control of hsp70B promoter in a murine tumor model [1]. Thermal stress has been identified as the primary mechanism to regulate the gene expression. However, the natural heterogeneity and opacity of solid tumors has hindered direct correlation of site-specific gene expression level with in situ thermal dosimetry. We have developed a homogeneous and transparent cell-embedded tissue mimicking phantom as an alternative for simultaneous assessment of temperature distribution, HIFU lesion formation, and gene expression.

Copyright © 2007 by ASME

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