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Effect of Oxygen-Radio Frequency Plasma Treatment on Three Dimensional Poly(ε-Caprolactone) Scaffolds

[+] Author Affiliations
Eda D. Yildirim, Selçuk Güçeri, Wei Sun

Drexel University, Philadelphia, PA

Paper No. MSEC2007-31169, pp. 117-124; 8 pages
  • ASME 2007 International Manufacturing Science and Engineering Conference
  • ASME 2007 International Manufacturing Science and Engineering Conference
  • Atlanta, Georgia, USA, October 15–18, 2007
  • Conference Sponsors: Manufacturing Division
  • ISBN: 0-7918-4290-8 | eISBN: 0-7918-3809-9
  • Copyright © 2007 by ASME


In the present study, the effect of oxygen-based plasma treatment on the three dimensional poly (ε-caprolactone) (PCL) was analyzed in terms of surface wettability, surface energy, and surface biocompatibility. The surface treatment was carried out for 1, 3, and 5 minutes durations on three dimensional PCL scaffolds at atmospheric pressure using a radio frequency (RF) plasma treatment system. The solid surface energies of the modified and unmodified PCL scaffolds were calculated by using the Owens-Wendt’s method. To examine the effect of oxygen plasma treatment on cell-scaffold interaction, mouse osteoblast cell line (7F2) was used. Oxygen plasma treatment contributed in decreasing the hydrophobicity of PCL for the 1-min treatment. A change in the surface energy from 39.98 mN/m for untreated to 52.54 mN/m for 1-min treated was observed by the increment in the polar component of surface energy. However, with the extended treatment times (3-min, and 5 min), the hydrophilicity, and the surface energy remained unaffected. The highest mouse osteoblast cells proliferation rate was observed for the 1-minute treated sample.

Copyright © 2007 by ASME



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