Full Content is available to subscribers

Subscribe/Learn More  >

Thermal Management Design of a Nanoscale Biocalorimeter

[+] Author Affiliations
Gregory J. Kowalski, Amir Talakoub

Northeastern University, Boston, MA

Dale Larson

Harvard Medical School, Boston, MA

Paper No. IPACK2007-33404, pp. 939-946; 8 pages
  • ASME 2007 InterPACK Conference collocated with the ASME/JSME 2007 Thermal Engineering Heat Transfer Summer Conference
  • ASME 2007 InterPACK Conference, Volume 2
  • Vancouver, British Columbia, Canada, July 8–12, 2007
  • Conference Sponsors: Electronic and Photonic Packaging Division
  • ISBN: 0-7918-4278-9 | eISBN: 0-7918-3801-3
  • Copyright © 2007 by ASME


A nanoscale calorimeter design based on temperature induced changes in a surface plasmon based photonics effect has the potential to decrease the mass of experimental compounds consumed and to increase the throughput of experiments investigating drug development. This calorimeter is based on a demonstrated surface plasmon biosensor in which index of refraction changes as small as 10−5 % caused by biochemical reactions on the sensor surface are detected. To achieve this sensitivity require that the device’s temperature be held constant to within ± 0.001 K. In the biosensor the temperature was held constant to measure the concentration changes. For the calorimeter the concentration is held constant and temperature changes are monitored. In the calorimeter design the nanohole array sensor will be used as a sensitive thermometer that will be used to determine the enthalpy of binding, equilibrium binding constant and entropy changes of biochemical reactions. The numerical analysis described in this work demonstrates that nanoscale calorimetry is possible. The simulations demonstrate that two designs can produce temperature rises of 5.5 and 40 C, respectively well above the (10−3 ) C resolution of the sensors. These results were obtained using less than three orders of magnitude less reactants than is currently being used in calorimetry studies which is a significant advance of this technology.

Copyright © 2007 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In