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Processing Considerations for Salicylic Acid-Based Polymers

[+] Author Affiliations
Eva Wagner

Drexel University, Philadelphia, PA

Kathryn Uhrich

Rutgers University, Piscataway, NJ

Thomas Twardowski

Philadelphia University, Philadelphia, PA

Paper No. IMECE2003-55130, pp. 27-31; 5 pages
doi:10.1115/IMECE2003-55130
From:
  • ASME 2003 International Mechanical Engineering Congress and Exposition
  • Textile Engineering
  • Washington, DC, USA, November 15–21, 2003
  • Conference Sponsors: Textile Engineering Division
  • ISBN: 0-7918-3729-7 | eISBN: 0-7918-4663-6, 0-7918-4664-4, 0-7918-4665-2
  • Copyright © 2003 by ASME

abstract

This paper describes some of the processing issues for extruding salicylic acid-based polymer prodrugs into fibers for medical devices. Polymeric prodrugs, in which a drug is polymerized in a degradable polymer that delivers controlled quantity of the drug to a targeted site in the body as the device degrades, are a new approach to controlled release. Hollow fibers were produced by solution spinning. Solid fibers were formed by melt processing. The salicylic acid polymers exhibited shear-thinning behavior. The viscosity exhibited pronounced temperature dependence.

Copyright © 2003 by ASME
Topics: Polymers

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