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Numerical Simulation of Freezing of Biological Tissue

[+] Author Affiliations
Dawei Luo, Dayong Gao

University of Kentucky, Lexington, KY

Liqun He, Shuxia Cheng

University of Science and Technology of China

Paper No. IMECE2003-43346, pp. 467-470; 4 pages
  • ASME 2003 International Mechanical Engineering Congress and Exposition
  • Heat Transfer, Volume 4
  • Washington, DC, USA, November 15–21, 2003
  • Conference Sponsors: Heat Transfer Division
  • ISBN: 0-7918-3718-1 | eISBN: 0-7918-4663-6, 0-7918-4664-4, 0-7918-4665-2
  • Copyright © 2003 by ASME


Cryosurgery, the use of controlled freezing process to destroy tissues, has become an accepted treatment for many diseases. Knowledge of the temperature transients of tissues during the controlled cooling is critical to the success of cryosurgery. In this article, a transient heat conduction problem involving freezing of biological tissue is investigated. Based on the continuum model for multi-component phase change system, a new unified equation, which can be applied to frozen, partially frozen and unfrozen tissue region has been developed. In this equation, for the unfrozen region, the influence of blood perfusion has been taken into account. A one dimensional problem was solved numerically. The results predict the temperature profile in the tissue with a controlled cooling rate boundary.

Copyright © 2003 by ASME



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