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In Vivo Experimental Study of Brain Temperature Distribution in Rats During Head Surface Cooling

[+] Author Affiliations
Chenguan Diao, Liang Zhu

University of Maryland Baltimore County, Baltimore, MD

Paper No. IMECE2003-41994, pp. 425-427; 3 pages
doi:10.1115/IMECE2003-41994
From:
  • ASME 2003 International Mechanical Engineering Congress and Exposition
  • Heat Transfer, Volume 4
  • Washington, DC, USA, November 15–21, 2003
  • Conference Sponsors: Heat Transfer Division
  • ISBN: 0-7918-3718-1 | eISBN: 0-7918-4663-6, 0-7918-4664-4, 0-7918-4665-2
  • Copyright © 2003 by ASME

abstract

In recent years, mild or moderate hypothermia during which brain temperature is reduced to 30–35°C has been proposed for clinical use as an adjunct for achieving protection from cerebral ischemia and traumatic brain injury [Busto et al., 1987; Dietrich 1992; Gal et al., 2002; Jiang et al., 2000; Stone et al., 1995]. Clinical data have suggested a 1–2 hour treatment window within which post-ischemic hypothermia must be instituted to confer any significant neuro-protection [Maier et al., 1997; Markgraf et al., 2001]. Based on the clinical and animal studies, it would be ideal to initiate hypothermia treatment in the pre-hospital settings.

Copyright © 2003 by ASME

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