Full Content is available to subscribers

Subscribe/Learn More  >

Analytical Porous Media Model of Light Penetration in Photodynamic Therapy

[+] Author Affiliations
Amaranath Premasiri, Gemunu Happawana

Southern Methodist University, Dallas, TX

Arye Rosen

Drexel University, Philadelphia, PA

Paper No. BioMed2007-38019, pp. 9-10; 2 pages
  • ASME 2007 2nd Frontiers in Biomedical Devices Conference
  • ASME 2007 2nd Frontiers in Biomedical Devices
  • Irvine, California, USA, June 7–8, 2007
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4266-5 | eISBN: 0-7918-3797-1
  • Copyright © 2007 by ASME


Photodynamic therapy (PDT) is currently being developed as a new therapeutic modality with minimal side effects in the treatment of many different types of cancers [1]. PDT requires three essential components, which includes a photosensitizing agent, activation light, and molecular oxygen [2, 3]. Light is one of the governing components for PDT, and the only component that can be controlled externally [4]. The understanding of light penetration in a tumor is critical for an efficient PDT protocol. A well-designed PDT protocol provides minimal microvascular damage and efficient killing of malignant tumor cells [5–7]. The depth of light penetration in a tumor depends on the microvascular nature of the tumor, amount of solid and liquid contents present, and the wavelength of the light source. The first two factors depend on the nature of the tumor tissue and therefore the optimal light dose is not standard for all tumors. Furthermore the liquid content of a tumor changes with the tumor temperature due to vasodilatation, and this in turn affects the depth of light penetration.

Copyright © 2007 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In