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A Diffusion-Based Approach for Nanobead Drag Forces

[+] Author Affiliations
Timothy W. Sirk, Eugene F. Brown

Virginia Polytechnic Institute and State University, Blacksburg, VA

Paper No. MNC2007-21206, pp. 1023-1026; 4 pages
  • 2007 First International Conference on Integration and Commercialization of Micro and Nanosystems
  • First International Conference on Integration and Commercialization of Micro and Nanosystems, Parts A and B
  • Sanya, Hainan, China, January 10–13, 2007
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4265-7 | eISBN: 0-7918-3794-7
  • Copyright © 2007 by ASME


A central process of the Bead ARray Counter (BARC) biosensor involves propelling a dilute solution of streptavidin-coated micron-scale beads through water. It is desirable to downsize these beads, leading to a basic engineering problem: What is the drag force acting on a nanoscale bead having an unknown hydrodynamic boundary condition? We use molecular dynamics simulation to estimate the drag force acting on a hypothetical biosensor “nanobead” without assuming a no-slip condition or a user-supplied slip parameter.

Copyright © 2007 by ASME



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