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Topology Optimization of MEMS-Based Biodegradable Controlled Drug Delivery System for Combination Therapy

[+] Author Affiliations
Ruixia Yu, Hualing Chen, Tianning Chen, Hairong Wang

Xi’an Jiaotong University, Xi’an, China

Paper No. MNC2007-21175, pp. 27-31; 5 pages
  • 2007 First International Conference on Integration and Commercialization of Micro and Nanosystems
  • First International Conference on Integration and Commercialization of Micro and Nanosystems, Parts A and B
  • Sanya, Hainan, China, January 10–13, 2007
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4265-7 | eISBN: 0-7918-3794-7
  • Copyright © 2007 by ASME


MEMS-based biodegradable controlled release system with micro multi-chambers can respectively enclose two drugs in different chambers to realize a combination therapy. In order to synchronously obtain the linear release of two drugs, it is necessary to completely investigate the topology optimization of the system. This paper introduces the theory of multi-objective topology optimization into MEMS-based biodegradable controlled release system for the combination therapy. Furthermore, a new method of CA-based evolutionary structural optimization (CA-ESO) is presented to accomplish the topology optimization of this controlled release system. The result shows that the optimized drug delivery system can achieve the objective of the synchronizing linear release for two drugs. The conclusion illustrates that the CA-ESO method proposed in this paper is validity for the topology optimization of MEMS-based biodegradable controlled release system.

Copyright © 2007 by ASME



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