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Digital Microfluidics: Connecting Biochemistry to Electronic System Design

[+] Author Affiliations
Krishnendu Chakrabarty

Duke University, Durham, NC

Paper No. ICNMM2007-30158, pp. 1007-1014; 8 pages
  • ASME 2007 5th International Conference on Nanochannels, Microchannels, and Minichannels
  • ASME 5th International Conference on Nanochannels, Microchannels, and Minichannels
  • Puebla, Mexico, June 18–20, 2007
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4272-X | eISBN: 0-7918-3800-5
  • Copyright © 2007 by ASME


Microfluidics-based biochips are revolutionizing high-throughput sequencing, parallel immunoassays, blood chemistry for clinical diagnostics, DNA sequencing, and environmental sensing. The complexity of microfluidic devices, also referred to as lab-on-a-chip, is expected to become significant in the near future due to the need for multiple and concurrent biochemical assays on multifunctional and reconfigurable platforms. This paper provides an overview of droplet-based “digital” microfluidic biochips. It presents early work on top-down system-level computer-aided design (CAD) tools for the synthesis, testing and reconfiguration of microfluidic biochips. These CAD techniques allow the biochip to concentrate on the development of the nano- and micro-scale bioassays, leaving assay optimization and implementation details to design automation tools.

Copyright © 2007 by ASME



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