Full Content is available to subscribers

Subscribe/Learn More  >

Synthesis and Chemical Functionalization of Ferromagnetic Nanoparticles to Manipulate Stem Cells Using External Magnetic Fields

[+] Author Affiliations
Miguel A. Méndez-Rojas, Claudia Cravioto Guzman

Universidad de las Américas Puebla, Puebla, Mexico

Oscar Arias-Carrion

Universidad Nacional Autónoma de México, Mexico City, Mexico

Paper No. ICNMM2007-30188, pp. 803-808; 6 pages
  • ASME 2007 5th International Conference on Nanochannels, Microchannels, and Minichannels
  • ASME 5th International Conference on Nanochannels, Microchannels, and Minichannels
  • Puebla, Mexico, June 18–20, 2007
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4272-X | eISBN: 0-7918-3800-5
  • Copyright © 2007 by ASME


The human brain is able to respond to several situations that promotes neural survivance, growth and neuronal cells regeneration. The potential of stem cells from the subventricular zone to be used for neuronal cell substitution has been widely studied. However, migration of endogen or transplanted cells is random, not efficient and with a very low survivance rate. The use of ferromagnetic nanoparticles may be of interest to guide the stem cells to the desired site using external fields. In this project, we have synthesized ferromagnetic nanoparticles (magnetite) with an average diameter of 10–12 nm, and functionalized with folic acid-flourosceine (with an average yield of 60–70%) in order to induce their entry into rat neuronal precursor cells in vivo and in vitro. The efficiency of cellular incorporation was low in vitro, observing clustering of the nanoparticles at the cytoplasm membrane. During the in vivo tests, no incorporation of nanoparticles was detected. Several results and perspectives are discussed in this work.

Copyright © 2007 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In