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Design and Modelling of a Micro Fluid Filter for Separating Spermatogenic Cells

[+] Author Affiliations
Xianghong Ma, Mark Prince

Aston University, Birmingham, UK

Mike Ward, Peter Docker

University of Birmingham, Birmingham, UK

Paper No. DETC2005-85357, pp. 475-480; 6 pages
  • ASME 2005 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 7: 29th Mechanisms and Robotics Conference, Parts A and B
  • Long Beach, California, USA, September 24–28, 2005
  • Conference Sponsors: Design Engineering Division and Computers and Information in Engineering Division
  • ISBN: 0-7918-4744-6 | eISBN: 0-7918-3766-1
  • Copyright © 2005 by ASME


The small size of microfabricated structures are opening new avenues in the field of biomedical engineering where structures are being developed to process [1] and analyze [2,3] nanolitre quantities of biological fluids, and cellular tissues. This paper outlines the design and manufacture principals of a passive micro-mechatronic device for the filtration and sorting of spermatogenic cells. This device is to be applied in a urological clinical environment where it can be used to semi-automate the spermatozoa selection process from non-obstructive azoospermic testis biopsies. Detailed and discussed herein are the advantages and drawbacks of Micro-Electro-Mechanical Systems (MEMS) as applied to clinical biomedical situations, and requirements for the design methodology and process of a microfluidic system based on MEMS technology with a view to manufacture by Deep Reactive Ion Etching process. The modelling of the micro device using computational fluid dynamic simulation methods is also covered in this paper.

Copyright © 2005 by ASME
Topics: Fluids , Design , Modeling , Filters



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