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Modeling Implications in Simulation-Based Design of Stents

[+] Author Affiliations
Tiefu Shao, Sundar Krishnamurty

University of Massachusetts, Amherst, MA

Paper No. DETC2006-99493, pp. 1169-1182; 14 pages
doi:10.1115/DETC2006-99493
From:
  • ASME 2006 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 1: 32nd Design Automation Conference, Parts A and B
  • Philadelphia, Pennsylvania, USA, September 10–13, 2006
  • Conference Sponsors: Design Engineering Division and Computers and Information in Engineering Division
  • ISBN: 0-7918-4255-X | eISBN: 0-7918-3784-X
  • Copyright © 2006 by ASME

abstract

Variations associated with stenting systems, artery properties, and doctor skills necessitate a better understanding of coronary artery stents so as to facilitate the design of stents that are customized to individual patients. This paper presents the development of an integrated computer simulation-based design approach using engineering finite element analysis (FEA) models for capturing stent knowledge, utility theory-based decision models for representing the design preferences, and statistics-based surrogate models for improving process efficiency. Two focuses of the paper are: 1) understanding the significance of engineering analysis and surrogate models in the simulation-based design of medical devices; 2) investigating the modeling implications in the context of stent design. The study reveals that the advanced nonlinear FEA software with analysis capacities on large deformation and contact interaction has offered a platform to execute high fidelity simulations, yet the selection of appropriate analysis models is still subject to the tradeoff between cost of analysis and accuracy of solution; the cost-prohibitive simulations necessitate the employment of surrogate models in subsequent multi-objective design optimization. A detailed comparison between regression models and Kriging models suggests the importance of sampling schemes in successfully implementing Kriging methods.

Copyright © 2006 by ASME

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