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Strain and Fracture Induced Changes in Bone Mineral Crystals

[+] Author Affiliations
Ozan Akkus, Mitchell B. Schaffler

Mount Sinai School of Medicine, New York, NY

Fran Adar

University of Toledo, Toledo, OH

Paper No. IMECE2002-32600, pp. 309-310; 2 pages
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME


The hierarchical organization of bone entails the tissue level at the nanoscale up to the organ level at the macroscale. In this hierarchical perspective, skeletal fragility is the outcome of a failure cascade that initiates at the molecular level, and propagates to higher levels [1]. This failure cascade is well investigated at the microscale and the macroscale [2] whereas the deformation and fracture mechanisms at the nanoscale are largely unknown. Therefore, our understanding of how mineralized tissues fail is incomplete and requires further investigations so as to formulate the ultrastructural basis of increased fracture susceptibility during disease and aging. In this regard, the first aim of the present study was to experimentally investigate the behavior of bone mineral under mechanical strain. The second aim of this study was to determine whether irreversible changes occur in the mineral crystals following fracture.

Copyright © 2002 by ASME



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