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Cell Adhesion and Deformation Under Dynamic Shear Flow in a Micro-Channel

[+] Author Affiliations
J. Xu, H. Zhang

State University of New York at Stony Brook, Stony Brook, NY

Paper No. IMECE2002-32789, pp. 267-268; 2 pages
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME


Progress has been made in the area of cell-fluid interaction considering deformation, adhesion, and rolling in a shear flow, for example, the seminal work of Dembo and colleagues [1]. Several other studies have also performed to provide a better understanding on the phenomena [2–4]. The dynamics of fluid flow and cell deformation add complexity to the complicated adhesion interaction problem. The objective of this study has aimed on developing a biomechanical model that can be used to predict the cell-endothelium interaction under the transient flow condition. To elucidate the roles of flow force, adhesion force, adhesion interaction, and cell deformation in leukocyte rolling under a shear flow, a model combining fluid-cell interaction and reaction-limited cell-substrate adhesion kinetics has been developed. In this paper, the cell is modeled as an elastic solid and fluid-cell interaction is modeled as the fluid-solid interaction.

Copyright © 2002 by ASME



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