0

Full Content is available to subscribers

Subscribe/Learn More  >

Generalizing the Theory of Microdialysis

[+] Author Affiliations
Rupak K. Banerjee

University of Cincinnati, Cincinnati, OH

Peter M. Bungay, Malisa Sarntinoranont

National Institutes of Health, Bethesda, MD

Srinivas Chippada

Fluent, Inc., Evanston, IL

Paper No. IMECE2002-32970, pp. 237-238; 2 pages
doi:10.1115/IMECE2002-32970
From:
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME

abstract

The efficiency of sampling or delivering solutes (analytes) by in vivo microdialysis is influenced by the diffusive permeabilities of the probe and the tissue in which the probe is implanted. In tissue, processes removing the analyte from the extracellular space are as important as diffusion in determining permeability. In addition to diffusion, analyte permeation through these media may be augmented or diminished by bulk fluid movement (transmembrane and interstitial convection). Within the perfusate, the dominant process is axial convection. Both diffusive and convective determinants of probe efficiency may be influenced by probe geometry (Figure 1; longitudinal cross-sectional view). The main geometric parameters are the probe membrane length and radii, but inner cannula geometry can also be an appreciable factor. The objective of this study is to generalize the mathematical description of microdialysis. The treatment extends in several ways previous mathematical models (Bungay et al. [1]; Morrison et al. [2]; Morrison et al. [3]; Wallgren et al. [4]). In addition to removing some simplifications and approximations and adding convective transport, the revised theory is applicable to low-molecular-weight lipophilic, as well as hydrophilic solutes. This is achieved by incorporating transcellular solute movement as a pathway paralleling interstitial diffusion. This change accompanies employing the combined intracellular and extracellular volumes, rather than the interstitial volume, as the basis for solute mass balances.

Copyright © 2002 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In