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Influence of the Fixed Negative Charges on the Measured Poisson’s Ratio, Young’s Modulus and Electrical Response of Articular Cartilage

[+] Author Affiliations
Morakot Likhitpanichkul, X. Edward Guo, W. Michael Lai, Van C. Mow

Columbia University, New York, NY

Daniel D. Sun

Johns Hopkins University, Baltimore, MD

Paper No. IMECE2002-32367, pp. 193-194; 2 pages
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME


Under physiological conditions, the solid extracellular matrix (ECM) of articular cartilage derives negative charges from its proteoglycan content [1]. The load-deformation behavior of the tissue (i.e., its apparent mechanical property) comes from not only the intrinsic matrix properties, but also these charges that are attached to the matrix. Study shows that in 1D configurations (such as confined compression), at equilibrium, the osmotic pressure associated with these fixed charges may contribute as much as 50% of the apparent compressive modulus [1–3].

Copyright © 2002 by ASME



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