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A Feasibility Study for Imaging Tissue Electroporation With Electrical Impedance Tomography

[+] Author Affiliations
Rafael V. Davalos, David M. Otten, Boris Rubinsky

University of California at Berkeley, Berkeley, CA

Lluis M. Mir

Institute Gustave-Roussy, Villejuif, France

Paper No. IMECE2002-33071, pp. 153-154; 2 pages
doi:10.1115/IMECE2002-33071
From:
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME

abstract

In tissue electroporation, electrodes are inserted around the targeted tissue and electrical pulses are applied to permeabilize the cell membrane to macromolecules such as gene constructs in genetic engineering or cancer treatment drugs [1, 2]. For a specific set of voltage parameters (e.g. pulse number, frequency, duration), the effect that the electric field has depends on the voltage gradients that develop across the individual cell [2].

Copyright © 2002 by ASME

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