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Finite Element Modeling of the Cryopreservation Protocols for a Bio-Artificial Liver Assist

[+] Author Affiliations
Saravana Kumar Balasubramanian, Robin N. Coger

University of North Carolina, Charlotte, NC

Paper No. IMECE2002-32560, pp. 125-126; 2 pages
doi:10.1115/IMECE2002-32560
From:
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME

abstract

Bio-Artificial Liver (BAL) devices have demonstrated potential as a temporary therapy for patients suffering from acute liver failure [1,2]. Of the variety of designs that exist [3], two BAL designs that have been tested clinically are the Hepatassist BAL [4] and the ELAD (Extra Corporeal Liver Assist Device) BAL [5]. To enable off the shelf availability of these devices, it would be helpful if they could be cryopreserved for safe low temperature storage. The aim of this study is to use finite element modeling to predict a suitable cryopreservation protocol for the Hepatassist BAL. Hepatassist incorporates a hollow fiber configuration in which nutrients (including oxygen) are supplied through the fibers to the hepatocytes surrounding the fibers [4]. In this study, we simulate the effects of different cryopreservation protocols in the presence of dimethyl sulphoxide (DMSO), a cryoprotective solution or cryoprotectant, on its integrity.

Copyright © 2002 by ASME

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