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A New System for Cyclical Tensile Loading of Cultured Connective Tissue Cells in a Three-Dimensional Gel Matrix

[+] Author Affiliations
Chantal Dussault, Dominic I. Young, Neil A. Duncan

University of Calgary, Calgary, Alberta, Canada

Paper No. IMECE2002-33601, pp. 101-102; 2 pages
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME


Cells can sense and respond to the mechanical load present in connective tissue. Cell shape has been correlated to the local mechanical environment in a variety of connective tissue cells [1,2], and cell deformation has been suggested as a mechanism to transduce tissue mechanical signals to the nucleus via the cytoskeleton [3,4]. Though many connective tissues are subjected to tensile loads, to date very limited investigations have been reported on the effect of tensile loads on the mechano-biology of isolated cells. To apply tensile loads to isolated connective tissue cells requires a three-dimensional (3D) matrix to maintain cell phenotype, and a highly elastic matrix to enable the large deformations that the cells experience in situ.

Copyright © 2002 by ASME



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