Full Content is available to subscribers

Subscribe/Learn More  >

Strategy for Tissue Engineering of Osteochondral Constructs

[+] Author Affiliations
Erica Takai, X. Edward Guo, Helen H. Lu, Michelle A. LeRoux, Priya Raina, Gerard A. Ateshian, Clark T. Hung

Columbia University, New York, NY

Paper No. IMECE2002-33595, pp. 97-98; 2 pages
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME


Damage to articular cartilage is a common condition affecting the joints of millions of people. This is a major problem considering the poor regenerative capacity of adult articular cartilage and the disability and pain that accompanies these injuries [13]. There exists a range of options that have been applied in clinical practice, with variable degrees of success, for repair of focal lesions and damage of the articular surface, including tissue adhesives [1,6,11,12,18], enzymatic treatments [8] and laser solder welding [21], autograft cell/tissue transfer via osteoperiosteal grafts [17], osteochondral grafts (mosaicplasty) [10] and Carticel [4,5]. The poor healing capacity of articular cartilage [13], potential for donor site pain and morbidity in autograft procedures, risk of disease transmission in allograft procedures, and the limited longevity of arthroplasty systems (i.e., ∼15 years for a total knee arthroplasty), has generated considerable research efforts to develop cell-based therapies for articular cartilage repair and replacement.

Copyright © 2002 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In