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Monte Carlo Simulation of Ice Formation in Tissues

[+] Author Affiliations
Daniel Irimia

University of Illinois, Chicago, IL

Jens O. M. Karlsson

Georgia Institute of Technology, Atlanta, GA

Paper No. IMECE2002-32681, pp. 89-90; 2 pages
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME


Freezing is a common technique for preservation of isolated cells, and extending its applications to the preservation of tissues would have important implications for the storage and distribution of tissue engineered products. Unlike isolated cells in suspension, cells in tissue interact with each other, and this interaction is known to affect the outcome of tissue cryopreservation. As a consequence, our knowledge of the cryobiology of isolated cells cannot simply be extrapolated to tissues, and new models, which consider the interaction between cells, need to be developed. The model that we propose is based on previous quantitative analysis of intercellular ice propagation in a micropatterned two-cell system. We used Monte Carlo simulations to extrapolate the results from cell pairs to two-dimensional and three-dimensional tissues. Effects of tissue geometry, cellular connectivity, and degree of intercellular interaction were investigated.

Copyright © 2002 by ASME



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