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Chondrocyte Death in Articular Cartilage Due to Excessive Mechanical Loading in the Axial and Transverse Directions

[+] Author Affiliations
Chih-Tung Chen, Peter A. Torzilli

Hospital for Special Surgery, New York, NY

Paper No. IMECE2002-32669, pp. 51-52; 2 pages
doi:10.1115/IMECE2002-32669
From:
  • ASME 2002 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • New Orleans, Louisiana, USA, November 17–22, 2002
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3650-9 | eISBN: 0-7918-1691-5, 0-7918-1692-3, 0-7918-1693-1
  • Copyright © 2002 by ASME

abstract

Chondrocyte injury and death in articular cartilage can cause matrix degradation and is a risk factor for secondary osteoarthritis [1,3–5]. Chondrocyte death can occur due to excessive mechanical loading, such as with a single high traumatic impact load (≥20 MPa), repeated sub-impact loads (≥5 MPa), or extensive cyclic loads (≥1 MPa) [1–5]. Several recent studies have shown that chondrocyte death depends not only on the stress magnitude [2] but also on the stress rate [3], strain rate [5] and load duration [1–2].

Copyright © 2002 by ASME

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