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A Selective Mixing in Microfluidic Systems Using Bacterial Chemotaxis

[+] Author Affiliations
Min Jun Kim, Kenneth S. Breuer

Brown University

Paper No. IMECE2005-80497, pp. 277-282; 6 pages
  • ASME 2005 International Mechanical Engineering Congress and Exposition
  • Fluids Engineering
  • Orlando, Florida, USA, November 5 – 11, 2005
  • Conference Sponsors: Fluids Engineering Division
  • ISBN: 0-7918-4219-3 | eISBN: 0-7918-3769-6
  • Copyright © 2005 by ASME


We demonstrate the use of Escherichia coli and their chemotactic characteristics to enhance mixing in a microchannel in a controlled and bi-directional manner. The presence of a chemoattractant in one arm of a three-junction microchannel results in an asymmetric increase in the effective diffusion coefficient of Dextran, which rises linearly with the concentration of attractant from a baseline value of 8 μm2 /s to 42 μm2 /s at a concentration of 0.1 M. The response to repellent is similar, with the opposite bias.

Copyright © 2005 by ASME



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