0

Full Content is available to subscribers

Subscribe/Learn More  >

Mechanical Neural Growth Models

[+] Author Affiliations
Kathleen B. Allen, Bradley E. Layton

Drexel University

Paper No. IMECE2005-79445, pp. 1-3; 3 pages
doi:10.1115/IMECE2005-79445
From:
  • ASME 2005 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • Orlando, Florida, USA, November 5 – 11, 2005
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4213-4 | eISBN: 0-7918-3769-6
  • Copyright © 2005 by ASME

abstract

Critical to being able to control the growth patterns of cell-based sensors is being able to understand how the cytoskeleton of the cell maintains its structure and integrity both under mechanical load and in a load-free environment. Our approach to a better understanding of cell growth is to use a computer simulation that incorporates the primary structures, microtubules, necessary for growth along with their observed behaviors and experimentally determined mechanical properties. Microtubules are the main compressive structural support elements for the axon of a neuron and are created via polymerization of α-β tubulin dimers. Our de novo simulation explores the mechanics of the forces between microtubules and the membrane. We hypothesize that axonal growth is most influenced by the location and direction of the force exerted by the microtubule on the membrane, and furthermore that the interplay of forces between microtubules and the inner surface of the cell membrane dictates the polar structure of axons. The simulation will be used to understand cytoskeletal mechanics for the purpose of engineering cells to be used as sensors.

Copyright © 2005 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In