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Lower Limits of Detection for Single Biological Particles Using Impedance Spectroscopy

[+] Author Affiliations
Pahnit Seriburi, Ashutosh Shastry, Angelique Van’t Wout, John Mittler, Shih-Hui Chao, John Koschwanez, Deirdre Meldrum

University of Washington, Seattle, WA

Paper No. NANO2005-87060, pp. 17-18; 2 pages
doi:10.1115/NANO2005-87060
From:
  • ASME 4th Integrated Nanosystems Conference
  • Design, Synthesis, and Applications
  • Berkeley, California, USA, September 12–14, 2005
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4208-8 | eISBN: 0-7918-3771-8
  • Copyright © 2005 by ASME

abstract

Single-cell impedance spectroscopy integrated with lab-on-a-chip systems provides a direct and minimally invasive approach for monitoring and characterizing properties of individual cells in real-time. Here we investigate the theoretical potential and limitations of this technique for analyzing single membrane-bound particles as small as 100 nm in diameter. Our theoretical model suggests a lower limit of detection for single cells on the order of a few microns.

Copyright © 2005 by ASME

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