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Cell-Surface Adhesive Interactions in Microchannels and Microvessels

[+] Author Affiliations
Michael R. King

University of Rochester, Rochester, NY

Paper No. ICMM2003-1011, pp. 103-108; 6 pages
doi:10.1115/ICMM2003-1011
From:
  • ASME 2003 1st International Conference on Microchannels and Minichannels
  • 1st International Conference on Microchannels and Minichannels
  • Rochester, New York, USA, April 24–25, 2003
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-3667-3
  • Copyright © 2003 by ASME

abstract

Adhesive interactions between white blood cells and the interior surface of the blood vessels they contact is important in inflammation and in the progression of heart disease. Parallel-plate microchannels have been useful in characterizing the strength of these interactions, in conditions that are much simplified over the complex environment these cells experience in the body. Recent computational and experimental work by several laboratories have attempted to bridge this gap between behavior observed in flow chamber experiments, and cell-surface interactions observed in the microvessels of anesthetized animals.

Copyright © 2003 by ASME

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