0

Full Content is available to subscribers

Subscribe/Learn More  >

Noninvasive Ultrasound Mediated Transdermal Transport of Insulin Across Ex Vivo Human Skin

[+] Author Affiliations
Nadine Barrie Smith, Seungjun Lee, K. Kirk Shung

Pennsylvania State University, University Park, PA

Paper No. PVP2002-1633, pp. 36-42; 7 pages
doi:10.1115/PVP2002-1633
From:
  • ASME 2002 Pressure Vessels and Piping Conference
  • Nondestructive Engineering: Applications
  • Vancouver, BC, Canada, August 5–9, 2002
  • Conference Sponsors: Pressure Vessels and Piping Division
  • ISBN: 0-7918-4661-X
  • Copyright © 2002 by ASME

abstract

The purpose of this research was to improve low frequency (20 kHz) ultrasound methods for enhancing the transport of insulin across ex vivo human skin. The feasibility of using ultrasound produced by small, lightweight novel transducers was explored for enhancing the transport of insulin across skin. Previous investigators have used ultrasound devices such as large, heavy sonicators or commercially obtained transducers for this type of research. These experiments used two low-profile novel ultrasound transducer arrays, the stack and standard array, for improved transport of insulin. The stack array was driven with a spatial peak temporal peak intensity (Isptp ) of 15.5 ± 2.0 mW/cm2 while the standard array had an Isptp of 173.7 ± 9.1 mW/cm2 . Spectrophotometeric absorption techniques were used for determining insulin transport across ex vivo human skin. Compared to passive transmission (6.3 ± 14.0 U/hr), the standard array facilitated a 6-fold increase in the noninvasive transdermal transport of Humulin® insulin (39.6 ± 11.7 U/hr). These promising results indicate that low frequency ultrasound can be used in a practical device for enhanced transport across the stratum corneum.

Copyright © 2002 by ASME
Topics: Ultrasound , Skin

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In