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Single Cell Electrophysiological Analysis via Sub-Micrometer Openings

[+] Author Affiliations
Sha Li, Liwei Lin

University of California at Berkeley

Paper No. IMECE2005-81765, pp. 33-36; 4 pages
  • ASME 2005 International Mechanical Engineering Congress and Exposition
  • Microelectromechanical Systems
  • Orlando, Florida, USA, November 5 – 11, 2005
  • Conference Sponsors: Microelectromechanical Systems Division
  • ISBN: 0-7918-4224-X | eISBN: 0-7918-3769-6
  • Copyright © 2005 by ASME


Single cell electrophysiological analyses were demonstrated via sub-micrometer openings using micro-and nano-machining technologies. In the prototype demonstration, a 6GΩ seal resistance was achieved on a HeLa cell, a cervical cancer cell line with size between 10~20μm, using the microfabricated electrophysiological system with opening size of 500nm in diameter and the measured electrolyte pipette resistance is 200kΩ. In a second experiment on a vacuolar yeast cell of 3~5μm in size, using a device with 800nm opening, a 500MΩ seal resistance was achieved and the measured electrolyte pipette resistance is 1MΩ.

Copyright © 2005 by ASME



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