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Modeling Hydrogel-Controlled Micro-Reactors for Enzyme Assays With Finite Elements for Improved Flow and Filling Distribution

[+] Author Affiliations
Philipp J. Mehner, Jing Tang, Anthony Beck, Denise Gruner, Mathias Busek, Uwe Marschner, Andreas Richter

Technische Universität Dresden, Dresden, Germany

Franziska Obst, David Simon, Dietmar Appelhans, Brigitte Voit

Leibniz-Institut für Polymerforschung Dresden e.V., Dresden, Germany

Paper No. SMASIS2018-8027, pp. V001T03A011; 7 pages
  • ASME 2018 Conference on Smart Materials, Adaptive Structures and Intelligent Systems
  • Volume 1: Development and Characterization of Multifunctional Materials; Modeling, Simulation, and Control of Adaptive Systems; Integrated System Design and Implementation
  • San Antonio, Texas, USA, September 10–12, 2018
  • Conference Sponsors: Aerospace Division
  • ISBN: 978-0-7918-5194-4
  • Copyright © 2018 by ASME


We propose an improved micro reactor design for a scalable microfluidic device, in which enzymes are immobilized in a hydrogel matrix. Furthermore, fluid flow is controlled by means of hydrogel-based micro-valves. In this work, computational flow simulations will be compared to experimental results to highlight new design ideas and to improve wetting and concentration distribution through the entire chamber volume, even for high aspect ratios. Additionally, modelling concepts will be introduced to efficiently describe multi-domain problems like enzyme reactions.

With the help of a computer-aided design process which is capable to simulate hydrogel-based microfluidic systems it is possible to better understand, predict and visualize the behavior of micro-reactors and support the development of highly integrated hydrogel-based microfluidic circuits.

Copyright © 2018 by ASME



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