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Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves

[+] Author Affiliations
A. Aggarwal, V. S. Aguilar, C. H. Lee, M. S. Sacks

University of Texas at Austin, Austin, TX

G. Ferrari, J. H. Gorman, R. C. Gorman

University of Pennsylvania, Philadelphia, PA

Paper No. SBC2013-14265, pp. V01AT04A006; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Splines are the standard tools in computer aided design for geometric representations and have been recently integrated into the finite element analysis of structures and fluids [1]. As the biomedical engineering is making progress, there is a need for an integrated tool for expanding the geometrical representation to include the microstructural details specific to soft tissue, e.g. fiber alignment, orientation, crimp and stiffness. In this work, a spline-based method is presented for aortic valves which facilitates mapping of the fiber structure from any aortic valve specimen to any other aortic valve geometry through a common parameter space. This techniques also has the ability to calculate mean tissue microstructure of representative population. Also strain and pre-strain from in-vivo state to the in-vitro state, where all the mechanical tests are done, are calculated for forward and inverse modeling of aortic valves.

Copyright © 2013 by ASME



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