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Hypoxia-Induced Changes in the Mechanical Properties of the Mouse Pulmonary Artery

[+] Author Affiliations
Ryan W. Kobs, Nidal E. Muvarak, Naomi C. Chesler

University of Wisconsin at Madison, Madison, WI

Paper No. IMECE2003-43086, pp. 259-260; 2 pages
  • ASME 2003 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • Washington, DC, USA, November 15–21, 2003
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-3710-6 | eISBN: 0-7918-4663-6, 0-7918-4664-4, 0-7918-4665-2
  • Copyright © 2003 by ASME


Hypobaric hypoxia produces pulmonary hypertension in mice which causes pulmonary vascular remodeling. To study the biomechanics of this process, mice were exposed to hypoxia for 0-(control), 10-, and 15-days. Using a pressurized arteriograph system, mechanical properties of the main pulmonary artery were measured and compared to the biological changes in the vessel wall measured histologically. 10- and 15-day hypoxic vessels were significantly stiffer when compared to 0-day vessels. This stiffness correlated with greater elastin and collagen content in the vessel wall.

Copyright © 2003 by ASME



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